Irritation Evaluation
Irritation evaluation can assist in assessing the possible local adverse effects of a drug. For example, our company has the capacity and the means to conduct professional irritation analysis for a rare disease therapy research and development thanks to our disturbance evaluation scientists. There are many ways to accomplish this, and we provide them all.
Overview of Irritation
Irritation is the pathological process that is expressed by inflammation and which is triggered after the administration of any parenteral preparations. The term is primarily used for assessing dermal, submucosal or ocular irritancy test for ascertaining the local toxicity of the preparation, and as an aid to the rational selection of method of administration, and the formulation of corrective measures to minimize or obliterate the irritant effects.
Fig.1 Examples of skin irritation evaluation. (Lulekal, E., et al., 2019) Methods of Irritation Evaluation
Rabbits tend to be intramuscularly injected and mice are intraperitoneally injected for measuring irritation on injections. The step of irritation evaluation has some procedures to follow which are, taking a local irritation test of the site area of the drug and later using observation and tissues biopsy to test the irritation and further observe the advancement and recovery of inflammation. As an illustration, perform local irritation and toxicity tests of the respiratory tract, particularly the lungs and other structures, observe the irritation of the conjunctiva and eyeballs, conduct toxicity and skin sensitization tests on pristine and broken skin.
The validity of transferring the results of irritation evaluation from animal tests to humans is very limited. When more than one strain of animals is used in experiments, the validity of transfer from animals to humans are more reliable. Our organization has a multi-species animal platform to serve your company's needs.
Our Services
The reliability of extrapolation of the results of irritation evaluation from animals to humans is limited. If similar results are obtained through experiments on multiple strains of animals, the reliability of extrapolation from animals to humans will be increased. Our company has a multi-species animal platform to meet your needs.
- Design of Irritation Evaluation
- Administration Route: design with reference to medication routes.
- Control Group: use the vehicle and/or excipient as a negative control, or use a marketed preparation as a control.
- Dosage Selection: design several experiments with different dosages or frequency of administration.
- Administration cycle: Generally, the maximum administration cycle is designed to be no more than 4 weeks.
- Observation: routine observation and histopathological examination.
- Statistical Analysis: choose appropriate statistical methods based on the experimental model and test methods.
- Content of Allergy Evaluation
Our company provides irritation evaluation services including but not limited to:
- Blood vessel stimulation
- Eye irritation/corrosion
- Vaginal mucosal irritation
- Skin irritation
- Ear irritation
- Mucosa irritation
- Rectal irritation
- Nasal drops and inhalant irritation
Why Choose Us?
- High-quality products and services
- Cost-effective compared to other companies
- Innovative and flexible solutions
- Automation-friendly workflow
- Access to a diverse pool of talent
Project Workflow
With extensive experience in rare disease therapy research and development, our company is capable of delivering an inexpensive and efficient solution to the clients. Our irritation evaluation service takes advantage of trained scientists and processes which simplifies the workflow. Our clients tell us that because we use our systems, we are able to offer exceptional services and high quality products to virtually every clients' appeal. If you are interested in our services, please feel free to contact us for more information.
Reference
- Lulekal, E., et al. "Phytochemical analysis and evaluation of skin irritation, acute and sub-acute toxicity of Cymbopogon citratus essential oil in mice and rabbits." Toxicology reports 6 (2019): 1289-1294.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.