PEGylated Peptide Development Service
Attaching polyethylene glycol chains to peptides has emerged as a powerful strategy of peptide therapeutics in rare diseases. Our company offers comprehensive PEGylated peptide services designed to enhance the stability, bioavailability, and efficacy of rare disease peptide-based therapeutics.
Introduction to PEGylated Peptides
In the realm of rare diseases, PEGylation of peptides holds immense promise as a therapeutic strategy. By attaching polyethylene glycol chains to peptides, their stability and drug delivery properties can be enhanced, addressing the specific challenges associated with treating rare diseases. PEGylation can help increase the half-life of peptides in circulation, allowing for longer-lasting efficacy and reducing the frequency of dosage administration. Overall, PEGylation offers a potential solution to optimize peptide-based therapies for the management of rare diseases.
Fig.1 PEGylated peptides can improve the efficacy of drug molecules (Kumar, Sumit, et al. 2020)
Application of PEGylated Peptides
- Enhancing drug stability: PEGylation can effectively slow down the rate of peptide degradation by enzymes, leading to prolonged residence time in the body.
- Reducing immunogenicity: The attachment of PEG chains to peptide molecules can mask immunogenic sites, making them less recognizable to the immune system.
- Improving drug delivery properties: PEGylation enhances the permeability of peptides across cell membranes. This has significant implications for tissue-targeted delivery and blood-brain barrier permeation of rare disease peptide drugs.
- Enhancing water solubility: Many rare disease peptide drugs suffer from poor water solubility. PEGylation enables the development of diverse formulations and delivery systems.
Our Services
Our company offers a comprehensive range of services for PEGylated peptides to meet the specific requirements of customers in the research and development of rare disease polypeptide drugs.
Design of PEGylated Peptides
When designing PEGylated peptides, consideration is given to multiple factors, such as PEG chain length, the site of modification, and the chosen linkage strategy. We meticulously evaluate the characteristics of the peptide, application needs, and the feasibility of synthesis methods to ensure optimal outcomes.
Preparation of PEGylated Peptides
Advanced techniques are employed in completing the PEGylation of peptides, targeting both terminal and side chain modifications. Our technicians perform PEG activation followed by binding with custom-synthesized peptides. Our purification methods, include but are not limited to gel filtration, and reverse-phase high-performance liquid chromatography.
Comprehensive Analytical
By utilizing techniques such as mass spectrometry and nuclear magnetic resonance, we can validate the successful PEGylation and characterize the final products.
Additional Functional GroupsGoing beyond simple PEG modifications, our company specializes in introducing additional functional groups onto PEG chains or peptide molecules, including but not limited to:
- Targeting ligands
- Fluorescent markers
- Radioisotopes
Our Advantages
- Cost-effective custom synthesis services
- Synthesis of monodisperse functionalized PEG derivatives
- Large-scale production capabilities
- Quality assurance
Our company offers comprehensive PEGylated peptide services, leveraging our expertise in protein bioconjugation, peptide synthesis, and advanced optimization strategies. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Kumar, Sumit, et al. "PEGylation and Cell-Penetrating Peptides: Glimpse into the Past and Prospects in the Future." Current Topics in Medicinal Chemistry 20.5 (2020): 337-348.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.