PEGylated Peptide Development Service
The process of adding chains of polyethylene glycol to peptides poses to be an invaluable approach with respect to peptide based therapeutics aimed at treating rare diseases. Our company provides PEGylated peptide custom services with the goal of improving the efficacy, bioavailability and stability of therapeutics targeting rare diseases.
Introduction to PEGylated Peptides
Out of many possible therapeutic approaches for rare diseases, PEGylation of peptides appears to be the most promising. The process of adding polyethylene glycol chains to peptides increases the stability and drug delivery capabilities of the peptides, allowing one to better tackle the issues associated with rare diseases. PEGylation can extend the active life of peptides in the blood system, thereby increasing efficacy and concurrently decreasing the amount of doses required. Hence, for the management of rare diseases, PEGylation offers a prospective answer to optimize peptide therapies.
Fig.1 PEGylated peptides can improve the efficacy of drug molecules (Kumar, Sumit, et al. 2020)
Application of PEGylated Peptides
- Enhancing drug stability: PEGylation can increase drug potency by slowing down the rate of degradation by enzymatic reactions.
- Reducing immunogenicity: Linking PEG chains to peptide molecules can hide the immunogenic epitopes making them less visible to the recognizing elements.
- Improving drug delivery properties: Peptide drugs for rare diseases greatly benefit from tissue-specific delivery and permeation of the blood-brain barrier for such drugs, as PEGylation improves the peptides' ability to permeate through biological membranes.
- Enhancing water solubility: A number of rare disease peptide drugs suffer from low water solubility. The ability to form multiple PEGylated constructions allows formulating novel drug delivery systems for such compounds.
Our Services
Our company offers a comprehensive range of services for PEGylated peptides to meet the specific requirements of customers in the research and development of rare disease polypeptide drugs.
Design of PEGylated Peptides
When designing PEGylated peptides, consideration is given to multiple factors, such as PEG chain length, the site of modification, and the chosen linkage strategy. We meticulously evaluate the characteristics of the peptide, application needs, and the feasibility of synthesis methods to ensure optimal outcomes.
Preparation of PEGylated Peptides
Advanced techniques are employed in completing the PEGylation of peptides, targeting both terminal and side chain modifications. Our technicians perform PEG activation followed by binding with custom-synthesized peptides. Our purification methods, include but are not limited to gel filtration, and reverse-phase high-performance liquid chromatography.
Comprehensive Analytical
By utilizing techniques such as mass spectrometry and nuclear magnetic resonance, we can validate the successful PEGylation and characterize the final products.
Additional Functional GroupsGoing beyond simple PEG modifications, our company specializes in introducing additional functional groups onto PEG chains or peptide molecules, including but not limited to:
- Targeting ligands
- Fluorescent markers
- Radioisotopes
Our Advantages
- Cost-effective custom synthesis services
- Synthesis of monodisperse functionalized PEG derivatives
- Large-scale production capabilities
- Quality assurance
Our company offers comprehensive PEGylated peptide services, leveraging our expertise in protein bioconjugation, peptide synthesis, and advanced optimization strategies. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Kumar, Sumit, et al. "PEGylation and Cell-Penetrating Peptides: Glimpse into the Past and Prospects in the Future." Current Topics in Medicinal Chemistry 20.5 (2020): 337-348.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.