Inquiry

Phototoxicity Evaluation

Phototoxicity evaluation is used to study the toxic response of a substance to the human body. Our company has long-term devoted to developing and applying rare disease drug safety evaluation. With years of experience, our scientists have the capabilities and resources to provide one-stop phototoxicity evaluation services to advance the rare disease therapy research and project goals of our global clients.

Introduction to Phototoxicity Evaluation

Phototoxicity refers to a toxic response caused by a substance applied to the body that is excited or increased after subsequent exposure to the light, or by skin irradiation after systemic administration of a substance. Preclinical phototoxicity evaluation is generally divided into in vivo evaluation and in vitro evaluation. Phototoxicity is a common phenomenon in humans and may cause damage to skin cells and tissues, such as edema, itching, stinging, skin cancer, cataracts, etc. Types of drugs that may have phototoxicity include:

Occurrence of Phototoxicity

Sunlight is composed of visible, infrared, and ultraviolet, each of which has a different wavelength range. Since some drugs convert to an excited state after absorbing energy at the corresponding wavelength, the excited state is converted to the ground state to absorb the transferred energy and generate reactive oxygen species (ROS), the increased ROS leads to the production and release of inflammatory mediators and cytokines by damaging DNA and cell membrane, and eventually leads to the occurrence of phototoxicity.

Our Services

With the continuous expansion and improvement of the company over the years, our company has a complete light source configuration and detection system. We can use a variety of light sources, including visible light, xenon arc solar simulator, and fluorescent UV radiation source, to provide customers with professional phototoxicity evaluation services, such as cutaneous phototoxicology, ocular toxicology, visceral phototoxicology, and other services.

Why Choose Us?

Project Workflow

With extensive experience in rare disease therapy research and development, our company provides customers with a cost-effective and convenient solution. Our phototoxicity evaluation service is a simplified workflow by a group of specially trained and professional scientists. We are pleased to use our advanced platform to offer the best service and the most qualified products to satisfy each demand from our customers. If you are interested in our services, please feel free to contact us for more information.

Reference

• Bauer, D., et al. "A cross-industry survey on photosafety evaluation of pharmaceuticals after implementation of ICH S10." Regulatory Toxicology and Pharmacology 125 (2021): 105017.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

• General Toxicology Evaluation
• Genetic Toxicology Evaluation
• Developmental and Reproductive Toxicity Evaluation
• Immunogenicity and Immunotoxicity Evaluation
• Local Toxicity Evaluation
• Tissue Cross-Reactivity Evaluation
• Safety Pharmacology Evaluation
• Toxicokinetics Evaluation