Physiochemical Studies
In vitro ADME screening for isolated medical disorders physiochemical studies are crucial. Our company has extensive expertise in rare diseases preclinical research, especially its pharmacokinetic aspects. We can professionally manage the communication and problem solving needed to complete whole physiochemical studies.
Physiochemical Studies in Pharmacokinetics
Studies of lipophilicity, stability, molecular size, ionization, hydrogen bonding, and solubility, among other concepts are critical for in vitro ADME studies. Advanced technologies incorporating robotic automated assays and highly selective and sensitive LC-MS have positioned high throughput screening (HTS) as a leading approach methodology of physicochemical studies.
Researching the drug candidate's physicochemical properties is very useful for studies on compound toxicity in drug discovery's early phases. For example, the greater the value of the log P, the less polar the compound is, and the higher the chance of experiencing unwanted side effects. Physiochemical properties support the toxicology studies as well as the pharmacokinetic screening of candidate compounds.
Fig.1 Parameters involved in ADME studies. (Choi, S., et al., 2022)
The advancement of technologies has transformed the study of physiochemical properties and significantly improved the efficiency of in vitro ADME screening, thus providing new avenues for rare disease drug discovery and innovative therapy development.
What Services Can We Provide?
Many of our company's physiochemical studies are available in multiple forms to suit the different stages of the rare disease drug discovery and development pipeline, providing a flexible approach to ADME screening. The physiochemical studies services we can provide include but are not limited to:
- Blood Plasma Partitioning
Our company can provide plasma partitioning services to help customers understand the distribution of drugs in red blood cells and plasma to avoid errors in the analysis of blood-derived pharmacokinetic parameters. - Chemical Stability
Our company has extensive experience and technology in chemical stability determination and can provide you with analysis of compound degradation due to hydrolysis, oxidation, photocatalysis, and chemical induction, and conduct stability testing in different dosing solutions. - Kinetic/Thermodynamic Solubility
Our company can provide thermodynamic solubility testing and kinetic solubility testing for the solubility analysis of compounds in solvents, aqueous buffer systems, or bio-relevant media. - Lipophilicity & pKa
Our company has an experienced team to provide LogD, LogP, and pKa analysis by utilizing techniques such as potentiometric titration, reversed-phase high-performance liquid chromatography (RP-HPLC), and thin-layer chromatography (TLC).
Why Choose Us?
- Reducing costs and time by enabling more efficient processes through service expertise
- Careful design and transparent operation process
- Fast and cost-efficient workflow
- Exceptional post-sales support
Project Workflow
As an integrated CRO, our company employs talented and highly trained scientists who focus on every aspect of rare disease drug development and research. Our team will customize experimental designs for your project according to your specific requirements. Please feel free to contact us for more information about our professional physiochemical studies services.
Reference
- Choi, S., et al., "Prediction of metabolizing enzyme-mediated clinical drug interactions using in vitro information." Translational and Clinical Pharmacology 30.1 (2022): 1.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.