Physiochemical Studies
Physiochemical studies are an important part of in vitro ADME screening in rare disease research. Our company has extensive expertise in rare disease preclinical research, particularly in pharmacokinetics. We have the capabilities and resources to provide professional communication and problem-solving support to carry out entire physiochemical studies.
Physiochemical Studies in Pharmacokinetics
The study of physiochemical properties involves the analysis of lipophilicity, stability, molecular size, ionization, hydrogen bonding, solubility, etc., which is an important part of in vitro ADME analysis. The development of new technologies with robotic automated assays combined with highly selective and sensitive LC-MS has enabled high-throughput screening (HTS) technology to play a major advantage in physicochemical studies.
In the early stages of drug discovery, studying the physicochemical properties of drug candidates is helpful for compound toxicity studies. Compounds with lower polarity and higher lipophilicity have an increased possibility of toxic events. The study of physiochemical properties provides data support for the study of toxicity and the pharmacokinetic screening of candidate compounds.
Fig.1 Parameters involved in ADME studies. (Choi, S., et al., 2022)
With the development of technology, the study of physiochemical properties has greatly accelerated the efficiency of in vitro ADME screening, bringing more possibilities for the discovery of rare disease drugs and the development of innovative therapies for rare diseases.
What Services Can We Provide?
Many of our company's physiochemical studies are available in multiple forms to suit the different stages of the rare disease drug discovery and development pipeline, providing a flexible approach to ADME screening. The physiochemical studies services we can provide include but are not limited to:
- Blood Plasma Partitioning
Our company can provide plasma partitioning services to help customers understand the distribution of drugs in red blood cells and plasma to avoid errors in the analysis of blood-derived pharmacokinetic parameters. - Chemical Stability
Our company has extensive experience and technology in chemical stability determination and can provide you with analysis of compound degradation due to hydrolysis, oxidation, photocatalysis, and chemical induction, and conduct stability testing in different dosing solutions. - Kinetic/Thermodynamic Solubility
Our company can provide thermodynamic solubility testing and kinetic solubility testing for the solubility analysis of compounds in solvents, aqueous buffer systems, or bio-relevant media. - Lipophilicity & pKa
Our company has an experienced team to provide LogD, LogP, and pKa analysis by utilizing techniques such as potentiometric titration, reversed-phase high-performance liquid chromatography (RP-HPLC), and thin-layer chromatography (TLC).
Why Choose Us?
- Reducing costs and time by enabling more efficient processes through service expertise
- Careful design and transparent operation process
- Fast and cost-efficient workflow
- Exceptional post-sales support
Project Workflow
As an integrated CRO, our company employs talented and highly trained scientists who focus on every aspect of rare disease drug development and research. Our team will customize experimental designs for your project according to your specific requirements. Please feel free to contact us for more information about our professional physiochemical studies services.
Reference
- Choi, S., et al., "Prediction of metabolizing enzyme-mediated clinical drug interactions using in vitro information." Translational and Clinical Pharmacology 30.1 (2022): 1.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.