Quantitative Tissue Distribution Studies
Quantitative tissue distribution studies can analyze the distribution of drugs in different tissues, to determine the metabolism and excretion pathways of rare disease drugs in the body, and provide an important reference for clinical research of rare diseases. Our company has extensive expertise in pharmacokinetics, we can provide efficient methods to accelerate your tissue distribution studies.
Introduction to Quantitative Tissue Distribution
Quantitative tissue distribution studies are an important part of pharmacokinetic analysis. There are several parameters involved in the drug tissue distribution process, such as blood perfusion, plasma protein and tissue binding, pH value, blood flow rate, partition characteristics, etc. These parameters affect the delivery, retention, and elimination of drugs in biological tissues.
Quantitative tissue distribution studies can provide information on the distribution and accumulation of compounds and their metabolites, identifying potential toxicity. The use of radiolabeled compounds to study tissue distribution is the most efficient method to quantitatively assess the localization of the parent molecule or its metabolites. Quantitative whole-body autoradiography (QWBA) and microautoradiography (MARG) techniques rely on the use of radiolabeled drugs and are commonly used to examine drug tissue distribution.
Fig.1 Typical cases of tissue distribution studies. (Kumar, M., et al., 2023) Quantitative tissue distribution studies can provide important information for the safety and efficacy evaluation of rare disease candidate drugs and are an integral part of the preclinical research of rare disease drugs.
Our Services
- Content of Quantitative Tissue Distribution Studies
With extensive experience and well-established technology in quantitative tissue distribution studies, our company provides a variety of animal models for in vivo experiments to accelerate your project's progress. The quantitative tissue distribution study services we can provide include but are not limited to:
- Blood-brain barrier studies
- Tissue half-life studies
- Target engagement extent studies
- Excretion route and rate studies
- Distribution or accumulation of drugs in specific tissues or organs studies
- Techniques of Quantitative Tissue Distribution Studies
The techniques of quantitative tissue distribution studies we can provide include but are not limited to:
- Quantitative whole-body autoradiography (QWBA)
- Microautoradiography (MARG)
- Workflow of Quantitative Tissue Distribution Studies
Sample collection and preparation
Formulating appropriate sample collection and preparation protocols according to the nature of the drug and the requirements of the clients.
Drug analysis
Using advanced drug analysis technologies, including LC/MS and ELISA, to detect and analyze drug concentrations in samples.
Tissue distribution evaluation
Evaluating the distribution of drugs in different tissues by measuring the drug concentration in the sample, including important parameters such as the metabolism and excretion pathways of the drug in the body and the half-life of the drug.
Data analysis and reporting
Conducting a comprehensive analysis of drug distribution in various organizations and write detailed reports for customers based on the research results.
Why Choose Us?
- Competitive pricing and fast turnaround time
- Professional technical support
- High data quality and reliable analysis
- Providing standardized upstream platform solutions
- High-quality one-stop service
Our company offers comprehensive services and technical support for every stage of rare disease research. Our extensive experience in providing quantitative tissue distribution study solutions allows us to provide you with customized services as well as comprehensive assistance that can help you move from rare disease therapy development to therapy commercialization. If you are interested in our services, please feel free to contact us for more information.
Reference
- Kumar, M., et al. "Nanoparticle biodistribution coefficients: A quantitative approach for understanding the tissue distribution of nanoparticles." Advanced Drug Delivery Reviews (2023): 114708.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.