The use of 2D cell models in the development and discovery of therapeutical solutions for skin diseases helps in understanding the disease processes and aids in drug screening and target identification. Protheragen is focused on improving drug discovery and therapy development for skin rare diseases by providing reliable 2D cell model development services.
2D Cell Models Development for Rare Skin Diseases
2D cell models are based on the growth of certain skin cell types like keratinocytes and fibroblasts into monolayer cultures to mimic the interactions among cells in the skin. Although more simplistic than 3D cell models, these systems provide a practical means of conducting initial screenings for drug efficacy and targeting specific cells to treat.
Fig.1 Schematic representation of
in vitro HSE build up. (Quilez, C.,
et al., 2024)
The development of novel cell culture and gene editing tools had dramatically improved the accuracy and applicability of 2D cell models, allowing them to capture the skin disease at a molecular biology level, which is critical in drug development.
Advantages of 2D Cell Models
Simplicity and Cost-Effectiveness
2D cell models are more convenient and economical than 3D models, enabling a wider range of drug screening due to less time and cost constraints.
High-Throughput Screening
With the aid of automation, the process of drug screening can be made more efficient with 2D cell models which makes it easier to find suitable therapeutic candidates.
Cell-Specific Insights
2D models created with particular skin cell types allow for the precise investigation of disease mechanisms and therapeutic targets at a cellular scale.
Our Services
At Protheragen, we focus on implementing and integrating a full range 2D cell model development services to aid research on rare skin diseases. Our team of scientists and researchers uses advanced technologies and extensive experience to focus on making 2D accurate and innovative skin models, ensuring precision and reliabilities during development, integration, and design of skin models.
2D Cell Models Development Services
In skin research for pathology, pharmacology, and cell biology, 2d cell models are very common. The illustrations below show representation of some of the 2D skin cell models with their features as well as their intended use in skin research.
| Model |
Characteristics |
Applications |
| Primary Keratinocyte Cultures |
Cultured directly from human skin tissues, primarily keratinocytes. |
Studying skin diseases, drug testing, cellular interactions, and wound healing. |
| HaCaT Keratinocyte Cell Line |
Immortalized human keratinocyte cell line used for skin disease studies. |
Skin regeneration, cancer research, UV exposure, and drug testing. |
| Fibroblast-Keratinocyte Co-culture |
Cultures involving both fibroblasts and keratinocytes to simulate skin layers more accurately. |
Study of cell-cell interactions, wound healing, skin barrier function, and inflammatory responses. |
| Immortalized Fibroblast Cell Lines |
Fibroblast lines that have been modified to proliferate indefinitely. |
Used for studying skin regeneration, fibrosis, and drug testing. |
| Transwell Models |
2D models cultured on permeable membranes to simulate skin barrier function. |
Studying skin permeability, drug absorption, toxicity, and barrier integrity. |
Types of Rare Skin Diseases
Protheragen has developed strong expertise in skin disease modeling and providing a variety of services in 2D cell model development, making it possible to meet the specific requirements of your research objectives. Since we understand the importance of skin disease modeling, we are ready to cover all the steps in 2D model creation and provide accurate, forward thinking, and tailored results to meet your scientific needs.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
