Drug Repurposing Services

In the quest for innovative solutions to rare skin diseases, Drug Repurposing Services have emerged as a promising approach, offering a faster and often more cost-effective path to new therapies. At our esteemed organization, we are committed to harnessing the potential of existing compounds to uncover new therapeutic applications.

Introduction to Drug Repurposing

Drug repurposing, also known as drug repositioning, involves the investigation of existing medications for new therapeutic purposes. Recent studies highlight its significance in expediting the drug development process, reducing costs, and improving success rates by leveraging known pharmacokinetics and safety profiles. This approach has gained momentum due to its potential to rapidly address unmet medical needs, especially in rare and complex diseases.

Fig.1 Advantages of drug repurposing over the traditional way of rare disease drug development. (Roessler, H. I., et al., 2021)

Approaches to Drug Repurposing

Drug repurposing, although not a novel concept, is now being approached with a more systematic and rational strategy due to technological advances. Today, the process leverages big data analytics, computer models, and high-throughput screenings to search for candidates, especially in the realm of rare diseases.

Computational Pharmacology and In Silico Methods:

The ability to generate vast amounts of data has led to the development of computational methods for drug repurposing. These methods effectively utilize target-based and ligand-based strategies to propose new drug indications, complementing experimental techniques.

Artificial Intelligence (AI):

AI, particularly through machine learning (ML), offers significant opportunities for drug repurposing by analyzing complex datasets and predicting new drug applications. By learning from sample data, ML algorithms can identify patterns and potential drug-disease connections without explicit programming.

Screening Assays:

Advances in screening technologies have shifted the drug discovery process from low-throughput to high-throughput methodologies. This transition allows for unbiased rescreening of existing compounds against various targets to identify new therapeutic potentials.

Collaborative Models:

Collaborative approaches involving academia, industry, government, and patient organizations are critical for successful drug repurposing. These partnerships leverage academia's disease insights and industry's resources to reduce risks and expenses, enhancing the drug development pipeline.

Successful Drug Repurposing Examples

By identifying new uses for known compounds, repurposing can accelerate treatment availability, especially for conditions with limited options. Table 1 provides selected examples of successful drug repurposing efforts and the specific approaches used, illustrating the impact of this strategy on advancing healthcare solutions.

Table1. Selected successful drug repurposing examples and the repurposing approach employed (Pushpakom, S., et al.,2019)

Disclaimer: Protheragen focuses on providing preclinical research services. This table is for information exchange purposes only. This table is not a treatment plan recommendation. For guidance on treatment options, please visit a regular hospital.

Our Services

At our company, we take pride in offering comprehensive drug repurposing services for rare skin diseases, designed to advance both diagnostic and treatment development. Our team of expert scientists and dermatologists utilizes state-of-the-art technologies and profound expertise to propel your projects forward, ensuring precision and innovation at every stage of development.

Workflow of Drug Repurposing Our Services

Identification and Screening

Begin by identifying existing drugs with potential new therapeutic uses. This involves high-throughput screening and computational analysis to ascertain their viability for different indications.

Preclinical Evaluation

Conduct extensive preclinical studies to assess the efficacy, safety, and pharmacokinetics of the repurposed drugs in various in vitro and in vivo models.

Data Analysis and Optimization

Analyze the preclinical data to optimize drug dosage, delivery methods, and anticipate potential challenges in further development stages.

In addition to our comprehensive workflow for drug repurposing, we offer a range of other preclinical services to support every stage of therapeutic development. Beyond identification, screening, and preclinical evaluation for repurposed drugs, our team is equipped to handle disease model development, drug metabolism and pharmacokinetics, and drug safety evaluation.

Diseases Model Development

Drug Repurposing Services

Drug Safety Evaluation

Drug Metabolism and Pharmacokinetics

Why Choose Us?

Our company is dedicated to transforming rare disease research through high-quality, end-to-end preclinical services. With a team of experienced scientists and cutting-edge technology, we provide tailored solutions from disease model development to pharmacokinetics and safety evaluation. Our rigorous, data-driven approach accelerates your therapeutic development with precision and reliability, minimizing risk and maximizing results. Choose us for a trusted partner committed to advancing your success in the complex field of rare disease therapies.

At our company, we are dedicated to offering extensive, one-stop preclinical development services, encompassing everything from disease model development to innovative therapy research. If you are interested in our services, please don't hesitate to contact us.

References

• Pushpakom, S., et al. "Drug Repurposing: Progress, Challenges and Recommendations." Nat Rev Drug Discov 18.1 (2019): 41-58.
• Roessler, H. I., et al. "Drug Repurposing for Rare Diseases." Trends Pharmacol Sci 42.4 (2021): 255-67.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.