Timely and precise diagnosis helps in progressing research work on rare skin diseases. Supported by advanced technological frameworks and vast domain knowledge, Protheragen specializes in developing state-of-the-art diagnostic kits. Our solutions are built to help simplify sophisticated diagnostic workflows and enhance experimental accuracy and reliability, enabling our pharmaceutical and academic partners to optimize resource expenditure and expedite project timelines.
Introduction to Skin Disease Diagnostic Kits
The complexity and variety of symptoms spanning across different genetic backgrounds makes certain skin conditions diagnose with relatively higher difficulty, thus leading to their arbitrary classification as rare. However, these systematic diagnoses can be made simpler by using diagnostic kits that measure unique biomarkers at the molecular level. Skin conditions of such nature can be identified due to the increase in research information technology diagnosis tools provide alongside their continuous advancement. For the purpose of drug targeting and gene studies, rare skin disease diagnostic kits can dramatically increase the efficiency and speed with which therapeutic solutions are put into action, showing the dire need for such tools.
Fig.1 Diagrammatic illustration of the main steps to build up the laminated lateral flow solid phase with a diagrammatic illustration of the building structures of each single lateral flow strip. ( Aboul-Ella, Sayed and Abo-Elyazeed, 2023)
Diagnostic Kits for Rare Skin Diseases
The scope of diagnostic testing for rare skin diseases has broadened due to the advances made in molecular techniques such as Next Generation Sequencing (NGS) and other high-throughput processes. The evolution in the genetic and molecular understanding of these diseases has cultivated a need for precise and swift diagnostic capabilities. These advanced diagnostic kits, with the information gathered from studying proteins which are biomarkers for the diseases, can greatly enhance the effectiveness of management and refinement of the understanding of these diseases.
Furthermore, these kits serve the dual purpose of assessing the progression of the disease and measuring the responsiveness of the patient to various therapeutic interventions. These diagnostic kits are extremely valuable in determining the status and activity of rare skin diseases.
Table1. Common Diagnostic Kit for Rare Skin Diseases.
| Kits |
Applications |
Detection Methods |
| Dystrophic Epidermolysis Bullosa (DEB) Mutation Detection Kit |
Identifies pathological mutations in the gene COL7A1 linked to dystrophic epidermolysis bullosa. |
PCR, Next Generation Sequencing (NGS) |
| Xeroderma Pigmentosum (XP) Gene Detection Kit |
Identifies genetic alterations linked to a rare condition of XP or xeroderma pigmentosum which leads to extreme sensitivity to UV radiation. |
PCR, Fluorescent Probe Technology |
| Pemphigus Vulgaris Autoantibodies Detection Kit |
Identifies autoantibodies in the diagnosis of pemphigus vulgaris, such as anti-desmoglein 1 and 3 antibodies. |
ELISA, Immunohistochemistry |
| Ichthyosis Gene Mutation Detection Kit |
Identified genetic mutations related to ichthyosis, rare skin disorder characterized by extreme dryness and scaling of the skin. |
PCR, Next Generation Sequencing (NGS) |
| Basal Cell Nevus Syndrome (Gorlin Syndrome) Detection Kit |
Identifies genetic changes associated with basal cell nevus syndrome (Gorlin syndrome) which predisposes patients to basal cell carcinoma and other skin lesions. |
Fluorescent PCR, Next Generation Sequencing (NGS) |
Our Services
At Protheragen we are devoted to developing the diagnostics kit for rare skin conditions. Our scientists study and analyse diagnostic biomarkers relevant to the aforementioned conditions and apply modern tools for efficient and precise diagnostic kit development. These kits facilitate diagnosis, accelerate disease management, and enhance the development of targeted therapies for rare skin disorders.
Workflow for Diagnostic Kit Development
Diagnostic Kit Design
Diagnostic Kit Optimization
Proof of Concept and Feasibility
Diagnostic Kit Verification
Types of Rare Skin Diseases
Based on our extensive experience, Protheragen provides the diagnostic kit development service specially tailored to the needs of your research. We possess the knowledge and capabilities for the complete development and production of diagnostic kits, drawing from our extensive experience in diagnostics development. Our team provides accurate and innovative solutions to support your scientific needs, ensuring that our diagnostic kits are reliable and up to date with latest advancements in rare skin disease research.
Why Choose Us?
Professional core technical team.
Advanced experimental equipment.
Empowering success through cooperation.
Strict quality control system.
Protheragen specializes in developing diagnostic kits for skin diseases as part of our integrated preclinical development service portfolio. From diseases model development to drug safety evaluation, our services support every stage of your research process. If you are interested in our services, please don't hesitate to contact us.
References
- Aboul-Ella, H., R. H. Sayed, and H. S. Abo-Elyazeed. "Development, Preparation, and Evaluation of a Novel Dotted Lateral Flow Immunochromatographic Kit for Rapid Diagnosis of Dermatophytosis." Sci Rep 13.1 (2023): 248.
- Li, Q., et al. "A Skin in Situ Immune Cell Detection Kit for the Diagnosis and Classification of Cutaneous Lupus Erythematosus." Ann Transl Med 9.13 (2021): 1062.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
