Syngeneic Model Development Service
Syngeneic models have become invaluable tools in preclinical research. Our company, a leader in the field, offers a comprehensive range of services in syngeneic model development. Through our cell line-derived models, genetic engineering services, and collaborative support, we empower researchers to advance their understanding of cancer biology, immune responses, and rare disease drug research strategies. By harnessing the power of syngeneic models, we pave the way for innovative discoveries and the development of rare disease drugs.
Introduction to Syngeneic Models
Syngeneic models, also called allograft models or allograft tumor systems, are a specific type of animal model used in research, where tumor cells from a mouse with a particular genetic background are transplanted into recipient mice that share the same genetic background. This category includes both cell-derived allograft and genetically engineered mouse (GEM)-derived allograft models. Among the commonly utilized host mice for traditional syngeneic transplantation models, Balb/c and C57BL/6 mice are the most prevalent.
Fig.1 Mouse models for studying brain metastasis in vivo. (Liu, Zihao, et al., 2024)Balb/c and C57BL/6 mice exhibit certain immunological differences. For instance, Balb/c mice tend to have a stronger humoral response compared to C57BL/6 mice. In C57BL/6 mice, Th1 immune responses and the production of interferon-gamma (IFNγ) are predominant, while Balb/c mice more readily elicit Th2 immune responses, among other distinctions. Numerous mouse tumor cell lines have been developed, primarily in the C57BL/6 and Balb/c genetic backgrounds.
Advantages of Syngeneic Models
- Immunocompetent Environment
One of the key advantages of syngeneic models is their immunocompetent nature. Unlike xenograft models that rely on immunodeficient mice, syngeneic models enable the evaluation of immune responses within a contextually relevant environment.
- Genetic Background Consistency
Syngeneic models maintain genetic background consistency between the tumor cells and the recipient mice. This genetic similarity ensures that the interactions between tumor cells and the immune system accurately represent the disease phenotype and response to therapies.
Our Services
At our company, we understand the importance of comprehensive support throughout the research process. From project inception to data analysis and interpretation, our team of highly skilled scientists provides guidance and expertise at every stage, including drug safety evaluation and pharmacokinetics research. We collaborate closely with researchers to design experiments, optimize protocols, and maximize the value of their studies. Our commitment to excellence and customer satisfaction ensures a seamless experience and empowers researchers to achieve their scientific goals.
B Cell-deficient Syngeneic Models
Why Choose Us?
- Comprehensive platform facilitated by a proficient technical team
- Meticulous planning and transparent workflow
- Superior data quality and dependable analysis
- Cost-effective pricing and rapid turnaround
- Highly qualified Ph.D. scientists and proficient technicians
- Vast expertise and cutting-edge platforms
Utilizing our profound expertise in rare disease therapy research and development, our company offers a cost-effective and convenient solution to our valued customers. Our syngeneic model development service streamlines the workflow through a dedicated team of highly trained and skilled scientists. We take pride in utilizing our state-of-the-art platform to deliver exceptional services and produce the highest quality products that cater to the unique requirements of each customer. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Liu, Zihao, et al. "Experimental models for cancer brain metastasis." Cancer Pathogenesis and Therapy 2.01 (2024): 15-23.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.