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Drug Absorption Studies

Drug absorption refers to the process whereby a drug is transferred from the site of administration to the blood circulatory system. Our company serves the niche market of preclinical stage drug development for rare diseases with high quality data and fast turnaround. We can undertake complete studies to assess absorption for a drug candidate targeting a rare disease.

What are Drug Absorption Studies?

Drug absorption is understood as how the drug, once administered into the body, reaches the systemic circulation in an unmetabolized state. This is further subdivided into gastrointestinal absorption and extra-gastrointestinal area absorption. Before entering into the circulatory system the drugs have to pass through various membranes of cells which are semi-permeable. The major types of drug absorption are three: passive transport, active transport, and other nonspecific transporters which largely depend on the drugs pharmacokinetic properties.

How are Drug Absorption Studies Performed?

Apart from direct intravenous injection, a drug's absorption relates to the route of administration, physiochemical traits, and the environment where it is absorbed, among others. Drug absorption studies can be conducted using in vitro or in vivo methods. For in vitro experiments, certain special models can be used for studies. For in vivo studies, animals are typically grouped into rodents and non-rodents, and the studied drugs are given by various routes (oral, intravenous, subcutaneous, intramuscular, topical, sublingual, and ocular) so that their absorption features can be established by determining their concentration in plasma.

What Services Can We Provide?

Different businesses would require different species of animals for the preclinical drug development phases. As part of our services, we are able to offer superior quality studies on the absorption of small molecular drugs, peptides, nucleosides, and nucleotides and even some biological macromolecular drugs. Our company ensures that the experimental designs developed for your project are tailored to your exact specifications.

There is a connection between absorption and drug metabolism, and the permeability of cell membranes is a vital factor in this process. Our company's services extend to providing the permeability study to facilitate the comprehensive characteristics of the drugs. Aside from the in vivo models of drug absorption, we offer in vitro models as Caco-2, and we will continue to meet the demand for responsiveness in drug absorption study services.

Project Workflow

Why Choose Us?

We employ some of the best-trained and skilled scientists focused on drug absorption studies for rare disease research. With the materials we have on hand, we are prepared to offer professional communications assistance, tackling issues to ensure rapid response to alterable requirements of your rare disease research projects. Please feel free to contact us for more information.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

• Quantitative Tissue Distribution Studies
• Bioavailability Studies
• Metabolite Profiling and Identification Studies
• Mass Balance Studies
• Biliary Excretion Studies