Idiopathic Pulmonary Fibrosis (IPF)
Idiopathic pulmonary fibrosis (IPF) is a lung condition that brings about the formation of scar tissue and thickening in the lungs. The complexity of IPF is not to be understated, with its intricate interplays within the realms of pulmonary health. Our distinguished company Delving deeper into the realm of rare disease research and therapeutic. Through the marriage of our expertise and cutting-edge technology, we aim to help your research of IPF.
Introduction to IPF
Idiopathic pulmonary fibrosis (IPF) with a prevalence of 5.6 per 100,000 individuals, and predominantly affects middle-aged and elderly men. IPF is characterized by persistent dry cough, escalating fatigue, and progressive breathlessness (Fig.1). Individuals diagnosed with IPF commonly face potential complications, including hypertension, chronic obstructive pulmonary disease (COPD), emphysema, diabetes, and gastroesophageal reflux disease (GERD).
Fig.1 Comparison of healthy lung to IPF lung. (Glass, D. S., et al., 2022)Pathogenesis of IPF
This pathological through the aberrant deposition of scar tissue within the pulmonary, which for the disruption of normal lung function and the subsequent deprivation of adequate respiration. At the crux of IPF lies the activation of fibroblasts, immune cells, and cytokines—a cascade that sets the stage for inflammation and fibrosis, further exacerbating the plight of those afflicted by IPF (Fig.2).
Fig.2 Cellular senescence is a key mediator of IPF pathology. (Moss, B. J., et al., 2022)Therapeutics of IPF
Small Molecule Drugs Therapy
Small molecule drug therapies, including pirfenidone and nintedanib, targeting TGF-β and FGF/PDGF pathways, respectively, have shown efficacy in slowing down disease progression.
Gene Therapy
Gene therapy approaches, like the knockdown of human antigen R (HuR), have shown potential in reducing the induction of extracellular matrix proteins by TGF-β.
Monoclonal Antibodies Therapy
Monoclonal antibodies, such as pamrevlumab targeting CTGF and romilkimab targeting IL13 and IL4, have demonstrated promise in halting the fibrotic process and reducing lung scarring in IPF individuals.
Cell Therapy
Cell therapy involving mesenchymal stem cells (MSCs) has emerged as a promising therapeutic modality in IPF. By infusing bone marrow-derived MSCs into individuals, researchers aim to regulate the fibrosis process and promote lung repair.
Our Services
At the forefront of the realm stands our company, equipped with a team of dedicated professionals, cutting-edge technology, and a commitment to advancing IPF research. We can provide crucial resources such as animal models and therapeutics platforms, to enhance your understanding of IPF and foster the exploration of new therapeutic modalities and intervention strategies.
Platforms of IPF Therapy Development
Animal Models of IPF
The animal models are valuable tools for studying the underlying mechanisms of IPF and for testing potential therapeutic interventions for the disease. Our company can provide chemical induction or genetic engineering animal models to support your research on the pathogenesis and preclinical therapeutic of IPF.
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| Bleomycin, lipopolysaccharide, silicon dioxide, or fluorescein isothiocyanate (FITC) are commonly used to induce lung fibrosis in animal models. They cause lung injury and inflammation leading to fibrosis, similar to the pathogenesis of IPF. | ||
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| Genetically Engineered Models | ||
| Transgenic or gene-editing techniques can be used to modify genes like TGF-β1 and SP-C in animals, leading to the development of progressive pulmonary fibrosis similar to IPF. | ||
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| Physical-induced models | ||
| Radiation exposure can also cause lung injury and fibrosis in animal models, mimicking the features of IPF. | ||
| Optional Models | Radiation-induced model | |
| Optional Species | Mice, Rats, Others | |
Our company focuses on providing comprehensive support throughout all stages of IPF research. From conceptualization to implementation, our seasoned researchers and advanced technology to support your pharmacokinetics research and drug safety evaluation, to guide and propel your research endeavors forward.
If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
References
- Glass, Daniel S, et al. "Idiopathic pulmonary fibrosis: Current and future treatment." The clinical respiratory journal 16.2 (2022): 84–96.
- Moss, Benjamin J, et al. "Pathogenic Mechanisms Underlying Idiopathic Pulmonary Fibrosis." Annual review of pathology 17 (2022): 515–546.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.