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Common Rare Orthopedic Diseases
- Osteogenesis Imperfecta,OI
- Achondroplasia
- Fibrodysplasia Ossificans Progressiva, FOP
- Marfan Syndrome
- Melorheostosis
- X-linked Hypophosphatemia, XLH
- Paget's Disease of Bone
- amyotrophic lateral sclerosis, ALS
- spinal muscular atrophy, SMA
- Rare Bone Tumors
- Klippel-Trenaunay Syndrome
- Ehlers-Danlos Syndrome, EDS
- Ultimate Guide to Rare Orthopedic Diseases Research Services
- Special Technology Service Platform
Rare Orthopedic Diseases EndureCART™ Platforms
At Protheragen, we recognize the challenges of advancing therapies for rare orthopedic diseases. Our EndureCART™ Platforms are specifically designed to empower biopharmaceutical innovation in this complex field. From target validation and mechanistic studies to therapeutic candidate development, we deliver end-to-end research services tailored to accelerate breakthroughs.
Introduction to EndureCART™ Platforms
Protheragen's EndureCART™ platform marks a significant advancement in CAR-T cell therapy created to fight rare orthopedic diseases and other rare conditions through immune system engagement. The platform seeks to strengthen CAR-T treatment effectiveness by addressing obstacles including distinctive microenvironment conditions and cellular diversity present in rare diseases. EndureCART™ technology activates T-cells sustainably by modifying chimeric antigen receptor structures to target particular tumor metabolites or stromal proteins which enhances therapeutic results.
Fig. 1 Mechanism of EndureCART™ CAR-T therapy.Our Services
Protheragen's One-stop CAR-T Therapy Development Platform offers a comprehensive suite of services to support the entire development process of CAR-T cell therapies. Utilizing advanced EndureCART™ technology, Protheragen ensures efficient and tailored services to meet the unique needs of each project. The services include:
CAR Design and Construction
- Target recognition and antibody development
- Design and construction of chimeric antigen receptors (CARs)
- Preparation of CAR lentivirus
CAR-T Cell Preparation
- Isolation and activation of T cells
- Viral or non-viral gene delivery to modify T cells
In Vitro Assay Services
- Validation of CAR expression
- Proliferation and cytotoxicity assays for CAR-T cells
- Cytokine detection to assess immune response
In Vivo Analysis Services
- Construction of animal models for therapy testing
- Pharmacodynamic evaluations to monitor efficacy
- Viability, bio-distribution, and toxicity assessments of CAR-T cells
Advantages of EndureCART™ Platforms
- Long-lasting Effects: Ensures persistent T-cell activation to deliver continuous therapeutic outcomes for rare diseases.
- Memory Therapy: Enhances T-cell memory capabilities for sustained elimination of disease-specific cells.
- High Safety Standards: Provides rigorous safety measures to reduce toxicity and therapeutic risks.
Our Advantages
Time-saving services with high efficiency
Professional and experienced scientists
Complete project designing and reporting
Numerous service cases and customer praise
Protheragen utilizes its CAR-T cell therapy expertise for rare diseases to optimize the EndureCART™ platform which advances CAR-T cell activation in target tissues thus supporting next-generation therapies that deliver enhanced safety and effectiveness. Please reach out to us for information about our services.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
