Recurrent Respiratory Papillomatosis (RRP)
Recurrent respiratory papillomatosis (RRP) is a rare and challenging benign airway tumor that is caused by HPV infection. This unique condition is characterized by wart-like growths in the airways, which can lead to voice impairment and airway obstruction. In the field of RRP disease research, our company possesses extensive experience and expertise, which can offer valuable support to further your investigations into this rare disease.
Introduction to RRP
Recurrent respiratory papillomatosis (RRP) is a rare disease, and the incidence rate slightly varies between children and adults, with approximately 4.3 cases per 100,000 children and 1.8 cases per 100,000 adults. Chronic viral disease is characterized by the growth of benign tumors (papillomas) in the respiratory tract, primarily the larynx and vocal cords. Individuals with RRP may experience symptoms such as hoarseness, chronic cough, difficulty breathing, stridor, and recurrent respiratory infections.
Fig.1 Outline of HPV type 6 and 11 infection pathways. (Ouda, A. M., et al., 2021)Pathogenesis of RRP
Pathogenesis of RRP involves initial infection, latency, and reactivation of the virus. RRP is caused by the HPV virus entering the body through mucosal surfaces, such as the respiratory tract, and infects the cells, causing them to multiply rapidly and form papillomas. The papillomas can grow and spread, leading to airway obstruction and voice changes. In severe cases, the tumors can extend into the lower respiratory tract and lungs, further exacerbating the condition.
Therapeutics of RRP
Small Molecule Drugs Therapy
Small molecule drugs, such as antiviral drugs (cidofovir and interferon) have demonstrated efficacy in therapeutic. Additionally, EGFR inhibitors (gefitinib), immunomodulatory drugs (alpha-interferon), and COX-2 inhibitors (celecoxib) have shown promise in suppressing papilloma growth.
Monoclonal Antibodies Therapy
Monoclonal antibody therapy has emerged as a promising approach for managing papilloma. VEGF pathway inhibitors (bevacizumab and avastin) and anti-PD-L1 monoclonal antibodies (avelumab) have shown the potential to reduce the size of RRP and improve therapeutic outcomes.
Vaccines Therapy
Vaccines play a crucial role in preventing and managing papilloma. HPV vaccines, such as Gardasil-9 and Cervarix, have been developed to induce humoral immune responses to prevent latent HPV infection, thereby reducing the severity of the disease and minimizing the risk of recurrence.
Our Services
Our company specializes in rare disease research and possesses a wealth of expertise in the field of RRP. We can provide animal models and therapeutic platforms, enabling researchers to delve into the intricacies of the disease's pathogenesis and explore novel therapeutic avenues.
Platforms of RRP Therapy Development
Animal Models of RRP
In the realm of RRP, animal models have emerged as indispensable tools for unraveling the complexities of this disease. Our company can provide virus-induced and genetically engineered animal models to support your research in this field and promote the development of novel therapeutic strategies.
| Virus-induced Models | ||
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| Employing intranasal or laryngeal inoculation techniques can induce the development of respiratory papillomatosis in animals. This model offers researchers a unique opportunity to study the dynamic virus-host interaction. | ||
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| Genetically Engineered Models | ||
| Genetically engineered models have also proven instrumental in RRP research. Manipulating the mouse genome to express viral oncoproteins, can lead to the development of epithelial hyperplasia and malignancy. | ||
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| Xenograft Models | ||
| In this model, human papillomatous tissues are transplanted into animals with low immune function, which can then be used for researching different therapeutic interventions. | ||
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| Optional Species | Mice, Rats, Rabbit, Non-Human Primates, Others | |
Our company offers a range of services tailored to support your research in RRP endeavors, which can support your pharmacokinetics analysis and drug safety evaluation. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
References
- Ouda, Amr Mohamed et al. "HPV and Recurrent Respiratory Papillomatosis: A Brief Review." Life (Basel, Switzerland) 11.11 (2021): 1279.
- Benedict, Jacob J, and Craig S Derkay. "Recurrent respiratory papillomatosis: A 2020 perspective." Laryngoscope investigative otolaryngology 6.2 (2021): 340-345.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.