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Single-dose Toxicity Evaluation

Single-dose toxicity evaluation is used to understand the toxic reactions and severity of animals after administration. Our company has extensive expertise in general toxicology evaluation, particularly in single-dose toxicity evaluation, our professional technical team and comprehensive service platform can provide efficient methods to accelerate your development of rare disease therapy.

Introduction to Single-dose Toxicity Evaluation

Single-dose toxicity evaluation is used to describe the relationship between dose and systemic and/or local toxicity. The purpose is to determine the potential acute adverse effects of the test compound and also to help researchers determine the dose for repeated-dose toxicity evaluation. Single-dose toxicity evaluation can determine the maximum tolerated dose (MTD) and identify potential target organs affected by the compound. In this type of study, the safety of a new drug candidate is typically tested in rodent and non-rodent models, with test animals given a single dose of the compound and all animals monitored for toxicity for 14 days.

Our Services

With extensive experience, our company's toxicologists can select appropriate dose levels for your toxicity studies and design the best experimental protocol. We can provide a complete range of animal species to support in vivo evaluation of single-dose toxicity. At the same time, we have highly sensitive and high-precision analysis methods including HPLC, LC/MS, etc., which can fully meet your scientific research needs.     

• In Vivo Toxicity Evaluation

Single-dose toxicity studies are performed in animals according to the experimental protocol. The dosage is enough to monitor the toxicity of all animals for 14 days and provide feedback to customers on the progress of the experiment at any time.

Animals Species

Routes of Administration

• Toxicity Analysis of Samples

Providing analysis of plasma, whole blood, and urine samples from experimental animals, euthanizing surviving animals, and performing complete necropsy and histopathological examination to assess potential toxicity where possible.

• Content of Single-dose Toxicity Evaluation

Our Advantages

• The rich experience accumulated in successful cases of new drug development
• Customized services and products tailored to your research
• Ph.D.-level scientists and skilled technicians
• High data quality and reliable analysis
• Fast and cost-efficient workflow
• One-stop platform with an experienced technical team

Project Workflow

With a research team with extensive expertise in rare disease therapy research and development, our company is confident in providing customers with single-dose toxicity evaluation services for rare disease therapy research and development. We have the capabilities and resources to provide professional communication and problem-solving support to ensure that we can quickly respond to the changing needs of your research projects. If you are interested in our services, please feel free to contact us for more information.

Reference

• Saleem, U., et al. "Acute oral toxicity evaluation of aqueous ethanolic extract of Saccharum munja Roxb. roots in albino mice as per OECD 425 TG." Toxicology Reports 4 (2017): 580-585.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

• Repeated-dose Toxicity Evaluation