Esophageal Diseases
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Rare esophageal diseases encompass a diverse group of uncommon conditions affecting the esophagus like Barrett's esophagus and gastroesophageal reflux. Diagnosing and managing these disorders can pose significant challenges due to their rarity. Our company specializes in developing therapeutics for rare esophageal diseases, providing a comprehensive range of advantages to our clients through our all-in-one service approach.
Rare esophageal ailments affect the functionality of the esophagus, the part of the digestive system responsible for transporting food from the mouth to the stomach. These disorders manifest with various symptoms, impacting swallowing, digestion, and overall quality of life.
Fig.1 Essential elements to be explored in the diagnosis and therapy. (Triadafilopoulos, G., et al., 2023)The pathogenesis of rare esophageal diseases varies depending on the specific condition. Some disorders may be present from birth, stemming from developmental abnormalities in the esophagus, while others may develop later, associated with factors such as autoimmune reactions, persistent inflammation, infections, or genetic changes. A deep understanding of the mechanisms behind these diseases is critical for successful therapeutic and control.
| Diseases | Drug Names | Mechanism of Action | Targets | Research Phase |
| Achalasia | Botulinum Toxin | Inducing brief paralysis in the muscles of the lower esophageal sphincter (LES) | Acetylcholine | Approved |
| Sildenafil | Reducing LES muscle tone and residual pressure | Phosphodiesterase-5 | Approved | |
| Eosinophilic Esophagitis | Jorveza | Activating corticosteroid receptors | Glucocorticoid receptor | Approved |
| Benralizumab | Monoclonal antibody to IL-5 receptor | IL-5 receptor | Phase III | |
| Lirentelimab | Monoclonal antibody to Siglec-8 | Siglec-8 | Phase II/III | |
| Esophageal Papillomatosis | HPMPC | Inhibiting the viral DNA polymerization process | DNA polymerase | Clinical trials |
Disclaimer: Protheragen focuses on providing preclinical research services. This table is for information exchange purposes only. This table is not a treatment plan recommendation. For guidance on treatment options, please visit a regular hospital.
Our team comprises experts with extensive expertise in rare esophageal diseases, ensuring that our clients receive exceptional guidance and assistance throughout the development process. By harnessing the latest research and technological advancements, we can offer you innovative diagnostics, therapeutics, and disease models of rare esophageal diseases, leading the way in field advancements.
Types of Esophageal Diseases
Therapeutic and Animal Model Development Services
Through our comprehensive services encompassing pharmacology, pharmacokinetics, and drug safety evaluation, we simplify the therapy development journey for our clients. Tailoring our offerings to meet each client's unique requirements, we deliver customized therapeutic approaches and research strategies to tackle the distinct challenges posed by rare esophageal diseases.
If you are interested in our services, feel free to contact us for additional information and pricing specifics.
Reference
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
