Bartonellosis, often referred to as Carrión's disease is a type of infection caused by the Bartonella, a sort of genus bacteria. Bartonellosis being one of the vicious types of infectious disease has always been a center of focus for our research, and vaccine and therapy development as we provision carry out cut edge diagnostics features.
Overview of Bartonellosis
Bartonella bacteria of different species can cause multiple diseases and disorders, Bartonellosis being one of them. These diseases and disorders include: Carrión's disease, cat scratch disease, trench fever, bacilli angiomatosis, peliosis hepatis, chronic lymphadenopathy, chronic bacteremia, infectious endocarditis and neurological conditions.
Chronic and undying infections are made possible since Bartonella species have devised ways to successfully suppress the immune system's response. This in turn promotes the disease progression associated with Bartonella. As these bacteria can infect red blood cells, lymph nodes, liver and skin, this results in various manifestations.
Fig. 1 Life cycle of Bartonella in the mammalian species. (Mada P. K., et al., 2023)
Vaccine Development for Bartonellosis
Membranous proteins such as Flagellin have become promising targets for vaccine development to curb Erythrocyte infection while Brps which display antigenic equivalence to TAA trimeric proteins may help in immune evasion and membrane adhesion. Other proteins such as FtsZ along with IALB possess significant immunogenic properties and structural uniqueness.
Therapeutics Development for Bartonellosis
Azithromycin, ciprofloxacin, gentamicin, trimethoprim-sulfamethoxazole and rifampin as antimicrobial therapy for Bartonellosis, has been effective in decreasing the length of symptoms and improving the results. The selection of the antimicrobial regimen is dependent on the manifestations of the disease and its severity.
| Bartonella disease |
Adults |
Children |
| Cat scratch disease |
No recommendation Azithromycin if extensive lymphadenopathy |
No recommendation Azithromycin if extensive lymphadenopathy |
| Carrion's disease (Oroya fever) |
Chloramphenicol + b-lactam or ciprofloxacin |
Chloramphenicol + b-lactam or ciprofloxacin or chloramphenicol or doxycycline + gentamicin |
| Carrion's disease (Verruga peruana) |
Doxycycline + gentamicin or streptomycin |
Rifampin |
| Trench fever and chronic bacteremia |
Doxycycline + gentamicin |
Unknown |
| Bacillary angiomatosis |
Erythromycin or doxycycline |
Erythromycin |
| Peliosis hepatis |
Erythromycin or doxycycline |
Erythromycin |
| Endocarditis |
Doxycycline + gentamicin or Ceftriaxone + gentamicin ± doxycycline |
Unknown |
Our Services
At our company, we offer comprehensive Bartonellosis vaccine and therapy development services tailored to meet the unique needs of our clients. Our team of experienced scientists and researchers work diligently to provide innovative solutions.
Infectious Disease Models
- B. elizabethae Infection
- B. tamiae Infection
- B. birtlesii Infection
- B. henselae Infection
- B. tribocorum Infection
- B. elizabethae Infection
Available Species: Swiss Webster, BALB/c, C57Bl/6, OF1, CD1, others
Our company provides a good preclinical research service to facilitate the development of a Bartonellosis vaccine and therapy. This encompasses in vitro assays, animal studies, pharmacokinetic and pharmacodynamic evaluations, as well as immunogenicity studies. If such services have captured your interest, we invite you to contact us so that you can get all necessary information and an appropriate estimate for services needed.
References
- Tahir A. H., et al. "Zoonotic importance of bartonellosis." Zoonosis, Unique Scientific Publishers, Faisalabad, Pakistan 4 (2023): 490-501.
- Mada Pradeep Kumar, Hassam Zulfiqar, and Andrew Stevenson Joel Chandranesan. "Bartonellosis." StatPearls [Internet]. StatPearls Publishing, 2023.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
