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Project Description

Please note that we are a research service provider, not a pharmacy or clinic, so we are unable to see patients and do not offer diagnostic and treatment services for individuals.

Syphilis

Syphilis can also be rechauffed as gradually developing disease with multiple stages which caused public health problems. We here at our company aim to foster syphilis vaccine and therapy development through the application of advanced research and services.

Overview of Syphilis

Syphilis is an STI with segmentation of primary, secondary, latent and tertiary stages which is characterized by typical features such as lesions, ulcers and even manifests systemically when untreated. The growth of syphilis has resurged through MSM and multiple sexual partners who are at the high risk of contracting syphilis. The cause of syphilis is a pathogen known as treponema pallidum which is a bacterium.

Immune response to TPA infection. Fig.1 Immune response to Treponema pallidum subspecie pallidum (TPA) infection. (Ávila-Nieto C., et al., 2023)

Vaccine Development for Syphilis

Because of the intricate immunobiology of Treponema pallidum, the manufacture of a syphilis vaccine has had its challenges. This particular strain bacterium has not responded to conventional strategies of producing the suitable vaccination such as inactivated, subunit and a variety of other bacteria vaccines.

Scientific developments have emphasized interest on the possibility of resuming efforts directed towards synthesis for a syphilis vaccine. Research interests has particularly tended towards the immune response of T. pallidum with a focus on the potential antigens that could be protective and the parameters which are associated with the immune response. Preclinical studies have explored the use of outer membrane proteins (OMPs) as potential immunogens. Advances in genetic engineering and bioinformatics have enabled the prediction of B cell epitopes and structural modeling of OMPs which are cornerstones of vaccination design.

Therapeutics Development for Syphilis

Antibiotic Therapy

Syphilis has primarily been treated with penicillin and its derivatives for a long time. In every grade of Syphilis, Benzathine penicillin G is the first line of therapy.

Combination Therapy

Current research has addressed the therapeutic effectiveness of BPG and ceftriaxone with doxycycline combined methods.

Alternative Antibiotics

Azithromycin and tetracycline derivatives have been considered for the treatment of syphilis most notably in individuals with penicillin allergies.

Our Services

The synthesis of effective vaccines and therapeutics for syphilis requires a multidisciplinary approach that combines the science with strong preclinical development. We offer such services on various lines of vaccine/therapy development:

Vaccine Development

Therapeutic Development

Disease Models

C57BL/6 Mice Models: Treponema pallidum (Nichols strain)
Hamster Models: intradermal infection
Rabbit Models: T. pallidum
Non-human Primate (NHP) Models: rectally transmitted syphilis

Preclinical studies consist of several complex tasks including but not limited to the assessment of safety and efficacy, studies of immunogenicity, and their combination. All potential vaccine candidates and therapeutic strategies are thoroughly evaluated using extensive preclinical models before advancing to any human clinical trials. Should you have any inquiries regarding our services please do not hesitate to be in touch.

References

Ávila-Nieto Carlos, et al. "Syphilis vaccine: challenges, controversies and opportunities." Frontiers in immunology 14 (2023): 1126170.
Drago, Francesco, et al. "A new enhanced antibiotic treatment for early and late syphilis." Journal of Global Antimicrobial Resistance 5 (2016): 64-66.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.