Peptide Conjugation Services
Peptide conjugation has revolutionized the field of peptide therapeutics for rare diseases. It makes peptides more suitable for research applications. Our company offers a full range of peptide conjugation services, which can help you make progress in the development of rare disease peptide therapies.
Introduction to Peptide Conjugation
Intrinsic limitations of peptides have impeded the development of effective rare disease drugs. The two major constraints in peptide drug development are their poor oral bioavailability and short half-life in the bloodstream. However, peptide conjugation offers promise. By attaching molecules to peptides, researchers can improve their drug capabilities and target delivery. This breakthrough approach improves bioavailability and stability, enhancing their therapeutic potential for rare diseases.
Fig.1 Peptide-drug conjugate is endocytosed by cells (Heh, Ethan, et al. 2023)
Advantages of Peptide Conjugation
- Extending Plasma Half-life: Conjugating peptides with moieties that increase their size, such as polyethylene glycol (PEG), allows them to evade kidney filtration, resulting in reduced clearance from the bloodstream, leading to sustained therapeutic effects.
- Enhanced Stability and Protection: The addition of conjugation can stabilize the structure of therapeutic peptides, minimizing enzymatic degradation. Glycosylation and encapsulation are forms of conjugation that offer protection from extracellular proteases, further increasing peptide stability.
- Improved Pharmacokinetics: Conjugating peptides with drugs that have inherent bioactivity allows them to follow the same metabolism and elimination routes as their endogenous counterparts. This compatibility with the body's natural processes enhances the pharmacokinetics of peptide conjugation, making them well-suited for therapeutic for rare diseases.
Our Services
Our company is dedicated to providing high-quality peptide conjugation services that cater to the specific needs for the research of rare diseases. Our expertise in the field of peptide synthesis allows us to offer customized solutions for peptide conjugation, ensuring optimal results for our customers. Our services include but are not limited to:
Project Workflow
With our extensive experience, cutting-edge technologies, and commitment to excellence, our company is the ideal partner for all your peptide conjugation service needs. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Heh, Ethan, et al. "Peptide Drug Conjugates and Their Role in Cancer Therapy." International Journal of Molecular Sciences 24.1 (2023): 829.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.