Peptide Conjugation Services
The incorporation of peptide drugs with therapeutics for rare disorders has been changed by peptide conjugation. It does augment the use of peptides in various fields of research. We can assist you in your challenges towards developing peptide therapies for diseases that are considered rare through our full range of peptide conjugation services.
Introduction to Peptide Conjugation
Making effective drugs for rare diseases has been a challenge due to the inherent problems with peptides. The poor oral availability and the short half-life of peptide drugs in circulation are the two most important hurdles in their development. Still, there is hope in peptide conjugation. The incorporation of molecules into peptides enables improvement on drug development and its controlled delivery. This innovation is improving bioavailability and stability and therefore helps to increase the possibility of treating rare diseases.
Fig.1 Peptide-drug conjugate is endocytosed by cells (Heh, Ethan, et al. 2023)
Advantages of Peptide Conjugation
- Extending Plasma Half-life: The conjugation of peptides with large structures like polyethylene glycol (PEG) prevents them from being filtered by the kidneys and therefore reduces their clearance from the bloodstream and prolongs their therapeutic effects.
- Enhanced Stability and Protection: Therapeutic peptides are prone to enzymatic cleavage but the structure of these peptides can be stabilized by conjugation. increased peptide stability can also be achieved using glycosylation and encapsulation which protects these peptides against extracellular proteases.
- Improved Pharmacokinetics: Joining peptides and drug entities possessing inherent biological activity makes it possible for them to undergo the same metabolic and excretion processes as their biologically active peptides. This preparedness enhances the pharmacokinetics of peptide conjugation making them appropriate for therapeutics of unusual ailments.
Our Services
Our company is dedicated to providing high-quality peptide conjugation services that cater to the specific needs for the research of rare diseases. Our expertise in the field of peptide synthesis allows us to offer customized solutions for peptide conjugation, ensuring optimal results for our customers. Our services include but are not limited to:
Project Workflow
Our company is oriented towards delivering high-quality peptide conjugate synthesis, contracted service for the study of rare diseases. Our extensive experience in the sphere of peptide synthesis gives us great opportunities for applying custom approaches to the transformation of peptides, making the projects successful. Our services, to mention, but a few, are as follows:
Our company has distinguished itself as proficient in undertaking a wide range of tasks within project expediency owing to the ease with which we adopt new ideas in conjunction with modern approaches techniques. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
Reference
- Heh, Ethan, et al. "Peptide Drug Conjugates and Their Role in Cancer Therapy." International Journal of Molecular Sciences 24.1 (2023): 829.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.