Thromboangiitis Obliterans (TAO)
Thromboangiitis obliterans, or Buerger’s disease, is a rare disease concerning blood vessels. With our experienced team of researchers and scientists whose area of expertise is in thromboangiitis obliterans, we are actively promoting progress in the development of new diagnostic methods and therapeutic agents. As your collaborator, we provide comprehensive, tailored services that meet your scientific research demands.
Overview of Thromboangiitis Obliterans
Thromboangiitis obliterans is a form of vascular disease that affects primarily the small and medium-sized arteries and, to a lesser degree, some of the superficial veins. This particular ailment affects the distal part of the limbs, causing ischemic damages of the arterial tissues and superficial thrombophlebitis. Thrombo angiitis obliterans is relatevely rare, with reported prevalence ranging between four to nine per 100,000 populations.
Fig. 1 Pathophysiological phases of thromboangiitis obliterans. (Piazza, Gregory, and Mark A. Creager., 2010)Pathogenesis of Thromboangiitis Obliterans
The major risk factor for the development of thromboangiitis obliterans is smoking, while the non-smoking population is affected rarely. The mechanism in which cigarette smoking causes Thromboangiitis obliterans is still unknown. There are some theories that claim that tobacco has the ability to activate an immune system in elderly individuals suffering from Thromboangiitis obliterans, as well as expose pre-existing coagulation disorders that cause vasculitis.
Strategies of Thromboangiitis Obliterans Therapy Development
Inhibit Inflammatory Response
Efforts aimed at responding to the thromboangiitis obliterans condition cannot be complete without taking into consideration the immune driven inflammatory response. Inflammatory response pathways can be modulated to develop new drug candidates, for example targeting interferon-6 or targeting tumor necrosis factor alpha. Corticosteroids and methotrexate, among other immunomodulators, decrease inflammation by activating immune cells.
Restore Endothelial Function
The dysfunction of the vascular endothelium is one of the main features that characterize thromboangiitis obliterans and is essential in the pathophysiology of this condition. The dysfunction leads to failure of vasodilation with increased adhesion molecules as well as greater platelet activation. Blood flow is also improved and the risk of thrombus rising is inhibited by the prostacyclin analogues iloprost and treprostinil, which function as vasodilator and platelet antagonist.
Our Services
Drawing upon our deep expertise in biotechnology and extensive experience in the industry, our company offers all-encompassing solutions for diagnostic and therapeutic research dedicated to thromboangiitis obliterans.
- Diagnostic Development Services: For rare genetic diseases such as thromboangiitis obliterans, our company offers diagnostic development services. We are committed to assisting you in developing advanced diagnostic tools for thromboangiitis obliterans to ensure accurate and timely testing.
- Therapeutic Development Services: Our company provides a wide range of services for the development of small molecule drug, cell therapy, gene therapy, therapeutic antibody, therapeutic peptide, and therapeutic protein. The robust platforms facilitate the research and development of therapies for thromboangiitis obliterans.
- Animal Model Development Service: To support the preclinical research and development of thromboangiitis obliterans therapeutics, we offer animal models development services to promote your pharmacokinetics study and drug safety evaluation.
| Induced Models | |
|---|---|
| Vascular inflammation is a hallmark of thromboangiitis obliterans. Our scientists have successfully induced vascular inflammatory responses in animals by administering pro-inflammatory agents such as lipopolysaccharide (LPS) or tumor necrosis factor-alpha (TNF-alpha). These models faithfully reproduce features associated with human thromboangiitis obliterans. | |
| Surgical Models | |
| Thrombosis and subsequent vascular occlusion are key pathological features of thromboangiitis obliterans. To replicate these aspects in animal models, our researchers use techniques such as ligation or surgical placement of constriction devices to induce vessel occlusion. | |
| Optional Species | Mice, Rats, Rabbits, Non-Human Primates (Baboons and Macaques), Others |
No matter what stage of research you are at, we can provide you with corresponding research services. If you are interested in our services, please feel free to contact us for more details and quotation information for related services.
References
- Piazza, Gregory, and Mark A. Creager. "Thromboangiitis obliterans." Circulation 121.16 (2010): 1858-1861.
- Li, Meng-di, et al. "Risk factors, mechanisms and treatments of thromboangiitis obliterans: an overview of recent research." Current Medicinal Chemistry 27.35 (2020): 6057-6072.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.