Angina Pectoris
Angina pectoris is a chronic disease characterized by recurring chest pain. Our company is committed to developing cutting-edge diagnostics and therapeutics for the management of angina pectoris. As your reliable partner in angina pectoris research, we offer streamlined and comprehensive solutions to meet all your scientific research requirements.
Overview of Angina Pectoris
Angina pectoris, a distinctive medical condition characterized by the presence of chest pain or pressure, arises primarily due to the inadequate supply of blood flow to the vital heart muscle. An estimated 10 million individuals in the United States grapple with the challenging realities imposed by angina pectoris. Angina pectoris is not only a common symptom of coronary artery disease but also an important indicator of underlying heart disease.
Fig. 1 Angina pectoris models and therapeutic targets. (Gallone, Guglielmo, et al., 2020)Pathogenesis of Angina Pectoris
Angina pectoris occurs when the heart muscle does not receive a sufficient supply of oxygenated blood. The primary cause of angina is coronary artery disease (CAD), which involves the accumulation of plaque within the coronary arteries. This plaque narrows the arteries, reducing blood flow to the heart and causing ischemia. The diminished blood flow results in inadequate oxygen and nutrient delivery to the heart muscle, leading to chest pain or discomfort.
Strategies of Angina Pectoris Therapy Development
Relax Blood Vessels
Vasodilation to improve coronary blood flow is an important target in the development of angina therapies. Nitroglycerin acts as a vasodilator by releasing nitric oxide. Calcium channel blockers, such as amlodipine and diltiazem, are employed to promote relaxation and dilation of blood vessels, thereby enhancing blood flow to the heart.
Reduce Heart Workload
Another target for therapy development is reducing the workload on the heart. Beta-blockers function by obstructing the effects of adrenaline, resulting in a reduction of heart rate and contractility. This action decreases the oxygen demand of the heart and can alleviate symptoms of angina.
Prevent Thrombosis
In addition, it is crucial to prevent the formation of thrombosis. Antiplatelet medications such as aspirin, clopidogrel, and ticagrelor play a vital role in preventing the formation of blood clots in the coronary arteries, thus reducing the risk of heart attacks.
Our Services
Our company leads the way in rare disease research and therapeutic development. Our experienced team of scientists and researchers is committed to unraveling the intricacies of angina pectoris and other rare diseases through the creation of advanced research platforms.
Research Platforms of Angina Pectoris
Utilizing cutting-edge technology, our goal is to strategize and develop diagnostics for angina pectoris to promote early identification and accurate diagnosis of the disease. With the establishment of angina pectoris animal models and comprehensive investigations into disease mechanisms and targets, we possess the capacity to develop therapeutic drugs for angina pectoris, thereby facilitating safety evaluation and pharmacokinetic studies of drug candidates.
Animal Models of Angina Pectoris
| Induced Models | |||
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| By administering certain chemicals or drugs, such as calcium chloride, elastase, angiotensin II, and isoproterenol, it is possible to induce vasoconstriction or increase cholesterol levels, leading to the development of atherosclerosis and subsequent myocardial ischemia. | |||
| Genetically Engineered Models | |||
| Our scientists use advanced genetic manipulation techniques to alter specific genes involved in the disease process to induce the development of angina-related phenotypes. This approach enables targeted studies of disease mechanisms and potential therapeutic interventions. | |||
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| Surgery Models | |||
| Surgical techniques are frequently used in the development of animal models of angina. Coronary artery ligation is a common surgical procedure used to induce myocardial ischemia. Additionally, surgical intervention can be used to model other aspects of the disease, such as atherosclerotic plaque formation. | |||
| Spontaneous Models | |||
| Spontaneous models of angina occur naturally in some animal species and provide valuable insights into the disease. For example, certain strains of transgenic mice exhibit spontaneous atherosclerosis, which may lead to coronary artery disease and subsequent angina-like symptoms. | |||
| Optional Species | Mice, Rats, Rabbits, Pigs, Others | ||
Regardless of your current research stage, we offer comprehensive research services tailored to your needs. If you are interested in our services, please don't hesitate to contact us for more information and a detailed quotation regarding the specific services you require.
References
- Gallone, Guglielmo, et al. "Refractory angina: from pathophysiology to new therapeutic nonpharmacological technologies." Cardiovascular Interventions 13.1 (2020): 1-19.
- Davies, Allan, et al. "Management of refractory angina: an update." European Heart Journal 42.3 (2021): 269-283.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.