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Project Description

Please note that we are a research service provider, not a pharmacy or clinic, so we are unable to see patients and do not offer diagnostic and treatment services for individuals.

Colorado Tick Fever

Colorado tick fever (CTF), which is emerging as a tick-borne infection, poses a considerable threat in terms of public health especially in the western part of North America. At our company, we are dedicated to advancing the understanding and research of Colorado tick fever through innovative vaccine and therapy development services.

Introduction to Colorado Tick Fever

Colorodo Tick Fever is an viral disease that has otherfactors affiliated with it. The Rocky Mountain Colitovirus is known to be affiliated with Colorado Tick Fever. This ailment tends to be caused when bitten by a wood tick (Dermacetor andersoni) and is found in southwestern Canada and western US. The tick virus was discovered around the 1940s while other historical tick viruses have been researched much more compared to this one like Lyme Disease.

Usually CTF persists for a longer period of time along with the symptoms of fever, chills, muscle aches, headaches etc. But in infrequent locations there have been results of mortality during the severe cases. The data surrounding the biology, epidemiology, and host interactions of CTFV is minimal which accounts for the deficient research of medical treatments and vaccines related to this disease.

A review of Colorado tick fever virus (CTFV) research. Fig.1 Historical milestones and development directions of CTFV research. (Harris, E. K., et al., 2023)

Vaccine Development for Colorado Tick Fever

Inactivated Vaccines

Vaccines made from inactivated CTFV are among the earliest vaccines constructed to combat the disease caused by CTFV. The strategy for developing inactivated vaccines consists of either a chemical or a physical method to destroy the virus and these allows the immune system to acknowledge and react to the viral elements. Thus, recent investigations of the effectiveness of inactivated CTVF have not developed to commercial stages as the vaccines potential to create an immune response and their safety are under question.

Live Attenuated Vaccines

The creation of a live attenuated vaccine has proven to be quite effective for some viruses as it has been able to create a form of the viral virus which is capable of replicating but will not lead to disease. Live attenuated vaccines for CFV have not been created as the safety issues regarding reversion to virulence have made the creation of the vaccine quite difficult. As such, the creation of the candidates for vaccines is still on going and satisfactory results are still yet to be achieved.

Therapeutics Development for Colorado Tick Fever

Antiviral Therapies

Presently, there are no approved antiviral therapies for CTFV infection. Symptomatic management without any specific therapeutic options is always the mainstay of the disease including relief measures against fever and pain. More importantly, developing specific therapeutics will profoundly influence the course of this infection, thus research into potential antiviral therapies targeting CTFV are warranted. Inhibiting viral replication or strengthening host immune responses with experimental antiviral compounds could be attempted as alternative therapeutic measures.

Host-Targeted Therapies

The development of CTFV treatments may benefit greatly from the pursuit of therapeutic strategies that target CTFV therapy. For instance, aiming to therapeutically alleviate the damage caused by CTFV infections or lessen the CTFV infection symptoms could be accomplished by altering the host's immune response. Therefore, outlining the crucial immune frameworks engaged within the response of a host to a treatment would help to facilitate the creation of more effective therapeutics.

Our Services

Our firm is focused on the formulation of vaccines and therapies targeted towards Colorado tick fever as part of the solutions to the challenges posed by this disease. The preclinical studies that we perform include designing of specific assays and creating animal models which replicate CTFV infection in humans. Such models assist us in gauging the immune parameters induced by our vaccines and also to test their effectiveness against the viral challenge.

Vaccine Development

Therapeutic Development

Infectious Disease Models

Mouse Infection Models
Hamster Infection Models
Golden-Mantled Ground Squirrels (Callospermophilus lateralis) Models
Non-human Primate Models

We believe in the power of collaboration to drive scientific advancements. Our team works closely with academic institutions and industry partners to share knowledge and resources, enhancing the overall development process. If you are interested in our services, please feel free to contact us.

References

Harris, Emma K., Brian D. Foy, and Gregory D. Ebel. "Colorado tick fever virus: a review of historical literature and research emphasis for a modern era." Journal of Medical Entomology 60.6 (2023): 1214-1220.
Padgett, Kerry A., et al. "Colorado tick fever virus in the far West: forgotten, but not gone." Vector-Borne and Zoonotic Diseases 22.8 (2022): 443-448.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.