Sporotrichosis

Sporotrichosis, which is caused by the dimorphic fungus Sporothrix schenckii, is a fungal infection caused by the pathogen sporothrix species. For such unusual diseases as sporotrichosis our company provides focused, high-quality services for the researchers and scientists working in the unique field.

Overview of Sporotrichosis

Sporotrichosis is primarily cutaneous mycosis that affects the skin, subcutaneous, and lymphatic system. Its most common form of transmission is through an accident or injury that exposes the skin to fungus mostly from infected soil or vegetation. Besides, being scratched or bitten by infected animals is another common way of getting the infection. There exist two main types of sporotrichosis: cutaneous and extracutaneous sporotrichosis.

Fig.1 Phylogenetic analysis of the main members of medical relevance in the genus Sporothrix. (Rodrigues, A. M., et al., 2022)

Pathogenesis of Sporotrichosis

Sporotrichosis is an infective disease that is caused primarily by the dimorphic fungus Sporothrix schenckii and its related species, which can be found in vegetation, decaying organic materials, Sphagnum moss, and soil around the world. This fungus penetrates the body through open skin, usually creating a small, soft bump that is not painful at the site of entry. The infection progresses along the lymphatic channels and may lead to a series of nodules or ulcers. In some cases, especially in those who are immunocompromised, the infection can spread to bones and joints and also the lungs.

Fig.2 The main antifungal agents and their cellular targets. (Rodrigues, A. M., et al., 2022)

Vaccine and Therapeutic Development for Sporotrichosis

Our Services

Our company specializes in infectious disease therapy development and has built great proficiencies in infectious disease modeling, vaccine and therapeutic development, and seamless service. We ensure that researchers looking for services or laboratory facilities have all the necessary tools to further their studies on sporotrichosis.

Featured Services for Sporotrichosis

Vaccine Development

• Live-attenuated Vaccine
• Inactivated Vaccine
• Toxoid Vaccine
• Viral Vector Vaccine
• Virus-like Particles Vaccine
• Protein Subunit Vaccine
• mRNA Vaccine
• DNA Vaccine

Therapeutic Development

• Small Molecule Drug Development Services
• Therapeutic mRNA Development Services
• Therapeutic Antibody Development Services
• Cell Therapy Development Services

Infectious Disease Models

• Systemic and peritoneal models of sporotrichosis in mice
• Subcutaneous model of sporotrichosis in mice
• Galleria mellonella model of Sporothrix schenckii infection
• Others

Our services bring a focus on accurate synergy with a plethora of resources and skillful expertise so that scientists and researchers can work towards eradicating diseases like sporotrichosis. To find out more about how to get in touch with our services, or for any other information or quotations related to our work, please do not hesitate to reach out to us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.