Rare Urticaria
Rare urticaria is a class of rare skin conditions involving hives and swelling. These conditions are usually complicated immunological responses that cause pain and itchiness and alter the quality of life for sufferers. Rare urticaria, unlike ordinary urticaria, is generally chronic, and it might be caused by an individual ‘idle’ trigger - mutations in the genes, for example, or a specific exposure to the environment.
Introduction to Rare Urticaria
Rare urticaria comprises several different subtypes with different triggering conditions and presentation.
-
Pruritic Urticarial Papules and Plaques of Pregnancy
This rare skin condition typically manifests during the third trimester of a first pregnancy, presenting as intensely itchy, red papules and plaques on the abdomen, buttocks, and thighs. Although uncomfortable, these symptoms usually resolve within weeks after childbirth.
-
Melkersson-Rosenthal Syndrome
Characterized by recurrent facial and lip swelling, a furrowed tongue, and facial nerve paralysis, Melkersson-Rosenthal syndrome typically begins in childhood or adolescence. Diagnosis often involves identifying non-caseating granulomas through histological examination.
-
Autosomal Dominant Vibratory Urticaria
This condition is characterized by localized hives and systemic symptoms following dermal vibration, due to mast cell degranulation and increased histamine levels. Management involves avoiding vibratory triggers and using antihistamines to relieve symptoms.
Our Services
At Protheragen , we specialize in cutting-edge drug discovery, offering comprehensive preclinical development services for rare urticaria. Our team has a strong grasp of cutting-edge technology and processes to ensure rapid drug development, and our solutions are tailored to address the special issues that come with rare urticaria research.
By Molecule Type
By Research Phase
Our Rare Urticaria Model Development Services
At Protheragen , we have expertise in the creation of rare urticaria models to capture the depth and complexities of rare urticaria as a therapeutic dynamic that is an essential part of rare disease research. These models help us assess the safety and efficacy of novel therapies and therefore can speed up the pipeline.
In Vitro Models
Our in vitro models enable detailed exploration of cellular behaviors and drug efficacy in rare urticaria, aiding in the identification of potential therapeutic targets and understanding disease mechanisms.
- 3D Bioprinting Models
- Organ-on-a-Chip Models
- Spheroids
- Microfluidic Cell Culture
- Organoid Models
In Vivo Models
Our in vivo models provide a holistic view of rare urticaria, supporting the evaluation of treatment strategies and offering insights into disease progression and systemic therapeutic responses.
- Genetically Engineering Model
- Induced Disease Model
- Humanized Animal Model
- Syngeneic Model
- Xenograft Model
With extensive expertise in rare disease R&D services, our company offers comprehensive support, ensuring swift responses to evolving research needs. Protheragen provides professional communication and assistance, from disease model development to innovative therapy research. For more details and quotation information, please contact us .
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
