Severe Dermatitis-Multiple Allergies-Metabolic Wasting Syndrome
Severe dermatitis-multiple allergies-metabolic wasting syndrome, or SAM syndrome, is a rare genetic disorder. It is marked by congenital erythroderma, severe dermatitis, ichthyosis, palmoplantar keratoderma, elevated immunoglobulin E, multiple food allergies, and metabolic wasting. Additional symptoms may include sparse hair, nail dystrophy, growth impairment, and recurrent infections. Protheragen’s specialty is new diagnostics and treatments that solve and help your research needs for SAM syndrome as quickly as possible.
Introduction to Severe Dermatitis-Multiple Allergies-Metabolic Wasting Syndrome
This syndrome is notable for its broad range of skin and immune system abnormalities, including severe dermatitis that appears at birth, leading to continuous skin scaling and inflammation. Patients often exhibit multiple allergies and elevated IgE, reflecting an underlying immune dysregulation. Metabolic wasting adds a layer of complexity, causing weight and growth issues. The autosomal recessive inheritance pattern suggests that the condition arises when both parents pass on a copy of the mutated gene. Symptoms generally begin early, during the newborn or infant stages, demanding a multi-disciplinary approach for accurate diagnosis and management.
Fig. 1 SAM syndrome histopathology. (McAleer MA, et al., 2015)
Our Services
At Protheragen, we specialize in cutting-edge drug discovery, offering comprehensive preclinical development services for SAM syndrome. Our team has a strong grasp of cutting-edge technology and processes to ensure rapid drug development, and our solutions are tailored to address the special issues that come with SAM syndrome research.
By Molecule Type
By Research Phase
Our SAM Syndrome Model Development Services
At Protheragen, we have expertise in the creation of SAM syndrome models to capture the depth and complexities of SAM syndrome as a therapeutic dynamic that is an essential part of rare disease research. These models help us assess the safety and efficacy of novel therapies and therefore can speed up the pipeline.
In Vitro Models
Our in vitro models enable detailed exploration of cellular behaviors and drug efficacy in SAM syndrome, aiding in the identification of potential therapeutic targets and understanding disease mechanisms.
- 3D Bioprinting Models
- Organ-on-a-Chip Models
- Spheroids
- Microfluidic Cell Culture
- Organoid Models
In Vivo Models
Our in vivo models provide a holistic view of SAM syndrome, supporting the evaluation of treatment strategies and offering insights into disease progression and systemic therapeutic responses.
- Genetically Engineering Model
- Induced Disease Model
- Humanized Animal Model
- Syngeneic Model
- Xenograft Model
With extensive expertise in rare disease R&D services, our company offers comprehensive support to ensure rapid responses to evolving research needs. From disease model development to innovative therapy research, we provide professional communication and assistance. For more detailed information or to request a quote, please get in touch with us.
Reference
- McAleer MA, et al. Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin. J Allergy Clin Immunol. 2015 Nov;136(5):1268-76.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.