Bacillus cereus is a bacterium that can cause a range of human diseases; it also causes a respiratory anthrax-like disease. Our company, which is well-known in the industry, excels in the Bacillus cereus infection vaccine and therapy development services.
Introduction to Bacillus Cereus Infection
Bacillus cereus is a gram-positive, spore forming bacterium which can be found in the enrivonment, soil, dust and food. Such infection can be classified into a number of forms, including gastrointestinal, ocular and respiratory infections such as anthrax etc. The infection caused by Bacillus cereus can be in many forms depending on the site and the person suffering from it.
Bacillus cereus infection is highly complex and involves an array of virulence factors and tropism determinants, which have been shown to have relation with the bacteria infectivity. The emetic type of food poisoning is associated with bacterial toxin known as cereulide, which is a cyclic peptide toxin that is produced by this bacteria. This preformed toxin is heat-stable and thus is not destroyed during cooking and leads to vomiting within max of hours during consumption.
Fig. 1 Diagrammatic representation of the transcriptional regulator PlcR in Bacillus cereus infection. (Gharib A. A., et al., 2020)
Vaccine Development for Bacillus Cereus Infection
In one case study, it proved that AVA can act as a protective shield against the Bacillus Cereus-mediated respiratory anthrax-like disease in mice. This transformation was brought about by the immunization done by AVA that caused the elevated antibodies to counter the threat posed by the protective antigen (PA1), this made them immune to the lethal advance of the bacteria.
These findings and other relevant discussions substantiate the expectancy of designing immunizations around protective antigens to mitigate infection from the Bacillus cereus .
Therapeutics Development for Bacillus Cereus Infection
In investigations that involved Anthrax-like diseases alongside the Bacillus cereus complex, it was established that such infections had strains that were relatively sensitive to the antiphlogistic anthrax medications. It has even been shown that novel antibacterials such as Vancomycin and Ciprofloxacin are efficient in combating the Bacillus cereus strains. Nevertheless, it is important to point out that resistance to certain antibiotics, including penicillins and cephalosporins, is often present in Bacillus cereus strains as a result of producing β-lactamase enzymes. This finding underlines the need to adopt targeted antibiotic therapy based on sensitivity testing parameters to optimize therapeutic outcomes.
As an organization, we take pride in offering every and any assist you may need in the streamlining of your therapy development, which is done through the use of a one-stop service. We would like to gain a better understanding of your expectations and the requirements that your therapy development entails through the option to click the link provided below.
Our Services
Since we are one of the top entities in the field of drug development for infectious diseases, we offer complete vaccine and therapy development against Bacillus cereus infection. Our efforts are directed at enhancing the comprehension of bacillus cereus pathogenesis as well as providing active measures against this infectious agent.
Our team of highly skilled scientists and researchers specializes in the development of Bacillus cereus infection animal models and in vitro models, enabling us to simulate and study the disease dynamics and assess the efficacy of potential vaccines and therapies.
Intraperitoneal Challenge Animal Models
One of the animal models which is primly helpful in studying the B. cereus infection is the intraperitoneal challenge model. This model is involved in abuse of B. cereus spores that are injected into the mouse’s peritoneal cavity. Our professional team picks the adequate B. cereus strain, achieves the optimized spore preparation and develops protocols to guarantee the outcomes are reproducible in nature and standard.
Aerosol Challenge Animal Models
Also apart from the intraperitoneal challenge model, aerosol challenge models are of great importance in studying the respiratory anthrax like disease caused by B. cereus strains. In this case, advanced tools and techniques are utilized to produce B. cereus spores in the form of aerosol which are then exposed to the animals to mimic the human respiratory infection.
Owing to our expertise and experience in the area we strongly facilitate other organizations in expediting their novel therapy concepts. In addition, if our services interest to you, we invite you to contact us for more details and request quotation for the needed services.
Reference
- Gharib A. A., et al. "Bacillus cereus: Pathogenicity, viability and adaptation." Adv. Anim. Vet. Sci 8.s1 (2020): 34-40.
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