The human respiratory system is infected by Bordetella pertussis and the most notable symptom is a cough lasting for weeks to months. As a matter of fact, our company is dedicated to offering unique pertussis vaccine and therapeutic development services so as to hasten R&D for pharmaceutical companies in the globe.
Overview of Pertussis
Whooping cough, also known as pertussis contagious, is a respiratory disease caused by the Bordetella pertussis bacterium. It was once one of the most important contributors to the mortality rate among children. The disease is marked with a distinctive persistent cough which is followed by a sound similar to a 'whoop' while gasping for breath. Even with the improvements in the vaccination, pertussis is still a big public health problem because of declining immunity, changing strains of bacteria, and vaccine denial.
Fig.1 Immunological responses to Bordetella pertussis infection. (Dewan K. K., et al., 2020)
Vaccine Development for Pertussis
The impact of the diphtheria vaccine for children and diphtheria, tetanus and whooping cough (DTaP) which is an acellular vaccine, has proved to prevent the widespread impact of whooping cough and its adolescents and adults. Despite these teams over coming the stands, a fair amount of challenges still remain.
An increased and in depth insight of the pathogenesis of the bacterium coupled with the understanding of the immune response fostered the progress in terms of varied medicines. Furthermore, crucial factors that have the ability to enhancing immunity include tetanus toxin, filamentous hemagglutinin, pertactin, pertussis toxin and their respective subunits.
Pertussis Toxin (PT)
PT which is detoxified is a key element of aP vaccines since it increases potency of the vaccine.
Filamentous Hemagglutinin (FHA)
FHA is adhesion factor for bacteria, and serves as antigen being one of the further factors of vaccine-elicited protective immunity.
Pertactin (PRN)
PRN is a prominent antigen in present day vaccines even though there are concerns about the lack of circulating strains.
Fimbriae (FIM)
Surface proteins that mediate bacterial adhesion, with antibodies against FIM showing potential as a correlate of protection.
Therapeutics Development for Pertussis
Apart from vaccines, it is also necessary to work on the development of therapeutic agents for pertussis. Antimicrobials like macrolides (e.g. azithromycin, clarithromycin) are the first line of treatment to decrease the severity of the disease and prevent transmissions. However, a shift in focus has also been directed to more passive treatment and medicines for the extreme cases. In addition, the exploration of new modes of therapy is aimed at elucidating the intricate relationships between the bacterium and host defence mechanisms, in order to decrease the severity of illness and associated complications.
Our company is aimed at the cutting edge of pertussis drug and therapy development solutions, based on years of experience amassed in this area. For more information, kindly follow the link below.
Our Services
All our personnel are determined to enhance pertussis prevention and therapeutics, thus we invest in a diverse range of research and development services. Our specialist assemblage of scientists alongside the researchers employs advanced scientific knowledge to lead the development of new pertussis vaccine and therapies.
- Chick Embryo Models: Infection was induced via chorioallantoic or yolk sac inoculation.
- Leporine (Rabbit) Models: intranasal or intratracheal inoculation
- Guinea Pig/Mouse/Rat Models
If our services appeal to you, do not hesitate to contact us. We offer capable preclinical research support which helps our partners improve on intervention candidates.
References
- Dewan, Kalyan K., et al. "Acellular pertussis vaccine components: today and tomorrow." Vaccines 8.2 (2020): 217.
- Nieves, Delma J., and Ulrich Heininger. "Bordetella pertussis." Emerging Infections 10 (2016): 311-339.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
